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学术活动(2014-9-12)


 

Seminar 15:00-17:00 September 12th,  2014 ,

        Meeting room, Floor 6 Building 3    

Presenter:  Prof. Peter Litter, Head of Pharmacy Program School of Medical Sciences, RMIT University, Melbourne, Australia

Chaired by: Prof. WenHua Zheng, Ocular Pharmocology.

Title: Role of proteoglycans in the aetiology of Age-related Macular Degeneration (AMD) – initial findings

AMD is a major cause of sight impairment and blindness. AMD has an early dry phase and later wet or proliferativephase. The majority of patients have dry AMD but treatments, mostly anti-proliferative, are aimed at wet AMD. There is norecognised treatmentfor early AMD. There is evidence for the deposition of blood derived lipids in association with the thickeningof Bruch’smembrane of the macular. The trapping of lipids in the blood vessel wall by modified proteoglycans is an established component of early atherosclerosis and the major modification is an elongation of the glycosaminoglycan (GAG) chains which increasesbinding to lipidsin vitro and in vivo. . On that basis we have commenced an investigation of the actions of growth factors and hormones on the proteoglycan production by the retinal endothelial and epithelial cells which are the major cell types in the macularpotentiallyproviding the proteoglycans to trap lipids. . Endothelial cells responded to many growthfactors with an increase in the size of the GAG but interestingly there was no response to VEGF. Epithelial cells did not produce any proteoglycans with known lipid binding proteoglycans but we discovered the phenomena of proteoglycan “shedding” in which treatment with a GPCR agonist lead to the releaseof a radiolabel proteoglycan from the cell surface. These initial results provide basis for further studies on thepossible role of proteoglycan in AMD and the longer term possibility of identifying a possible therapeutic target for early AMD.

 BIO 

ProfessorLittle is Head of the Discipline of Pharmacy and a ProgramLeader for Metabolism, Exercise and Disease Program of the Health Innovations Research Institute at RMIT University Melbourne Australia.

Professor Little is the Vice President of the Council of Pharmacy Schools of Australia (representing Heads of all Pharmacy Schools in Australia) and he was the National President of Diabetes Australia (2003 – 2006).

ProfessorLittle has published over 150 peer reviewed articles and reviews with over 500 ImpactsFactor points and almost 4,000 citations and his H index is 35 and RG score is 41.71.

ProfessorLittle holds a High-end ForeignExpertappointment in China for 2014 through Sun Yat-sen University in Guangzhou.

Professor Little is Regional Editor of the international journal Nutrition (Elsevier) and an Associate Editor of the Frontiers journal Cardiovascular Therapeutics and on the Editorial Board of many journals including J Pharmacy and Pharmacology, Clinical Science.

Professor Little’s researchinterests are the role of modified proteoglycans in diseasesinvolving the trapping of lipid in tissues such as atherosclerosis and Age-related Macular Degeneration (AMD). His laboratory is focusing on the signallingpathways that regulate the structure and synthesis of lipid binding proteoglycans such as biglycan and especially control of the lipid binding glycosaminoglycan (GAG) chains on the proteoglycans. Recentpublications have focussed on the role of G protein coupled receptor (GPCRs) mediated transactivation of tyrosine and serine/threonine kinase receptors in the stimulation of the expression of GAG synthesizing genes and also the role of Smad transcription factor phosphorylation and specifically linker region phosphorylation in the action of growth factors and hormones on biglycan synthesis.

ProfessorLittle’s other interests are pharmacy education and the role of the pharmacist inimproving the medicationquality and hence health outcomes for people with diabetes.

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